Tissue Regeneration in Dentistry
ZDEN-698 Tissue Regeneration in Dentistry
Fee: $49
Rescheduled date to be announced
Due to a water main break,
we had to reschedule this program.
We are working with the presenter to reschedule the
program
Additional Co-Sponsors:
T. John Megas, Jr., D.M.D.
For more Information, please call (413 - 755 4503) or Email CBT
Program Description
New and Emerging Concepts in Periodontal Tissue Engineering
Repair of alveolar bone defects caused by development abnormalities, trauma or disease is a major goal of oral reconstructive therapy. The field of tissue engineering combines advances in materials science and biology to repair tissues and organs. Periodontal and peri-implant tissue engineering has been achieved with limited success by the utilization of barrier membranes and block grafting techniques. Over the past decade investigators have begun to utilize growth factors to restore lost tooth support due to damage of the alveolus. This presentation will review emerging therapies in biomaterials, growth factor biology and cell/gene therapy with particular emphasis on recent clinical trial results using recombinant human platelet-derived growth factor (PDGF) and bone morphogenetic proteins (BMPs). The presentation will conclude with a future perspective on the use of novel biomimetic approaches and interactive regenerative materials for oral tissue engineering or defects around teeth and dental implants.
Implications of Bone Regenerative Biology on Periodontal Medicine
For nearly 100 years, it has been known that oral health can affect systemic well-being. However, not until the past decade has mounting evidence revealed the strong inter-relationships among oral disease and systemic disease and, in particular, the maintenance of oral bone mass. This presentation will highlight research on the etiology and pathogenesis of oral infection and how it can affect systemic bone volume including osteoporosis and osteopenia. The utilization of “bone-sparing” agents to preserve alveolar bone following regenerative therapy or in blocking progressive bone loss will be presented. The utilization of a variety of approaches including inhibitors of MMPs, osteoclasts and pro-inflammatory cytokines will be presented.
Presenter
William Giannobile, D.D.S., M.S., D.Med.Sc.
Dr. William Giannobile is The Najjar Endowed Professor of Dentistry
and Biomedical Engineering and the Director of the Michigan Center
for Oral Health Research at the University of Michigan School of
Dentistry. He received his D.D.S. and an M.S. in Oral Biology from
the University of Missouri and his Certificate in Periodontology and
Doctor of Medical Sciences in Oral Biology from Harvard University.
He subsequently completed postdoctoral training in Molecular Biology
at the Dana-Farber Cancer Institute and Harvard Medical School and
previously served as a faculty member at Harvard and the Forsyth
Institute in Boston. Dr. Giannobile completed his sabbatical year as
a Visiting Professor at the Biotechnology Institute of Regenerative
Medicine at the University of Genova Medical School in Genova, Italy
and at the School of Dentistry at the University of Milan.
Dr. Giannobile has published over 125 manuscripts, textbook chapters
and abstracts and has lectured extensively in the area of
Periodontal Regenerative Medicine and Tissue Engineering. Dr.
Giannobile is an Associate Editor for the Journal of Periodontology
and is on the editorial boards of the Journal of Clinical
Periodontology, International Journal of Oral & Maxillofacial
Implants and the International Journal of Periodontics & Restorative
Dentistry. He also serves as a consultant to the Food and Drug
Administration and the National Institutes of Health. Dr. Giannobile
is a Diplomate of the American Board of Periodontology and, in
addition to his faculty appointment at Michigan, he maintains a
private practice limited to periodontics and implantology in
Farmington Hills, Michigan.
